Case Reports
1 August 2025
Vol. 1 No. 1 (2023)
https://doi.org/10.4081/amsa.2023.36

Levosimendan off-label successfully used in two patients with exacerbated COPD and severe bronchospasm: a case series focusing on an explorative review of the current literature

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Levosimendan off-label, COPD, exacerbated COPD, case series, review
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Authors

Ludovica Golino
ludovica.golino@aslnapoli2nord.it
Unit of Anesthesia and Intensive Care, San Giovanni di Dio Hospital, Frattamaggiore (NA), Italy.
Marco Caiazzo
Unit of Anesthesia and Intensive Care, San Giovanni di Dio Hospital, Frattamaggiore (NA), Italy.
Pasquale Diglio
Unit of Anesthesia and Intensive Care, San Giovanni di Dio Hospital, Frattamaggiore (NA), Italy.
Espedito Tornincasa
Unit of Anesthesia and Intensive Care, San Giovanni di Dio Hospital, Frattamaggiore (NA), Italy.
Gianmarco Russo
Unit of Anesthesia and Intensive Care, San Giovanni di Dio Hospital, Frattamaggiore (NA), Italy.
Francesco Imperatore
Unit of Anesthesia and Intensive Care, San Giovanni di Dio Hospital, Frattamaggiore (NA), Italy.

Levosimendan was used off label to treat two patients with similar clinical and medical history (severe COPD, bronchospasm, cigarette smoking, difficult weaning). Starting from these two favorable cases, an explorative review of the current literature was conducted relating to this use of Levosimendan and its rationale.

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Levosimendan off-label successfully used in two patients with exacerbated COPD and severe bronchospasm: a case series focusing on an explorative review of the current literature. (2025). Advances in Anesthesia and Pain Medicine, 1(1). https://doi.org/10.4081/amsa.2023.36
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